Hier finden Sie die Publikationen unserer MitarbeiterInnen der letzten Jahre
Seit 1817 das erste Mal wieder komplett: die "Bibliotheca Electoralis", Bild vom 18.01.2008. Foto: Peter Scheere/FSU
Foto: Peter Schere
131 Publikationen filtern
Significance of Smelling Across the Lifespan (SoSAL)
Autoren
S. Li, T. Hummel, Q. Preusker, I. Croy, V. Schriever, J. Gellrich
Erscheinungsjahr
Erschienen in:
Journal of Sensory Studies
The significance of olfaction in human behavior is well recognized, yet there is a lack of standardized measurement tools applicable to all age groups. Particularly, children and the elderly currently lack specific standardized assessment instruments. This study included 454 healthy participants (154 children, 150 young adults, and 150 older adults). After three rounds of item screening and confirmatory factor analysis, we developed a 12-item questionnaire encompassing four dimensions: “Food,” “Hazards,” “Interpersonal Relationships,” and “Spatial Orientation.” The results demonstrate that the questionnaire exhibits good test-retest reliability and structural validity. Our findings indicate a positive correlation between the perceived importance of olfaction and age across a wide age range, but this trend does not reach statistical significance within any specific age group. Children scored significantly lower than both young adults and seniors, with no significant difference between the latter two groups. Additionally, trends were observed regarding gender differences in olfactory behaviors and variations across different olfactory activities. The present questionnaire is a reliable and validated self-report measurement of an individual's significance of olfaction for people over 10 years old.
How personality functioning shapes symptom development during and after treatment: a random intercept cross lagged panel analysis
Autoren
J. Fuchshuber, H. Kessler, A. Kehyayan, M. Pape, T. Hofmann, M. Rose, K. Imbierowicz, F. Geiser, I. Croy, K. Weidner, J. Rademacher, S. Michalek, E. Morawa, Y. Erim, M. Teufel, A. Bäuerle, S. Heinzmann, C. Lahmann, E. Peters, J. Kruse, D. von Boetticher, C. Herrmann-Lingen, M. Nöhre, M. de Zwaan, U. Dinger, H. Friederich, A. Niecke, C. Albus, R. Zwerenz, M. Beutel, C. Roenneberg, P. Henningsen, B. Stein, C. Waller, K. Hake, C. Spitzer, A. Stengel, S. Zipfel, K. Weimer, H. Gündel, S. Herpertz, S. Doering
Erscheinungsjahr
Erschienen in:
Comprehensive psychiatry: official journal of the American Psychopathological Association
Objectives: This study investigates the long-term influence of fluctuations around the individual's means of personality functioning (PF) on mental and physical symptoms in a large sample of patients receiving psychotherapy. Methods: We reanalyzed observational data of 2094 participants (68% female; age M = 39.89 years; SD = 14.20 years) which took part in the Multicenter Effectiveness Study of Inpatient Psychosomatic Psychotherapeutic Treatment (short: MEPP) at three time points. A Random Intercept-Cross Lagged Panel Model (RI-CLPM) was used to examine within-person longitudinal effects between PF (OPD-SQS) and depressive symptoms (PHQ-9), anxiety (GAD-7) and somatic symptom load (PHQ-15). The model was controlled for age, sex, treatment condition and treatment length. Results: Strong between-person intercorrelations were observed between all investigated constructs. At the longitudinal within-person level PF at hospital discharge predicted somatic symptom load (p < .01), depressive symptoms, anxiety and itself (all p < .05) at follow up, however, PF showed no effect during treatment (p > .05). Furthermore, depressive symptoms at baseline influenced general symptom burden and PF development during treatment (all p < .05) and showed strong effects on anxiety and somatic symptoms at follow up (p < .001). Conclusions: The results suggest a sustained influence of intraindividual PF deviations on general symptom development after psychotherapy, but also emphasize the effect of depressive symptoms in psychotherapy outcomes.
Long-Term Effectiveness of Inpatient and Day-Hospital Treatment of Eating Disorders in Departments of Psychosomatic Medicine and Psychotherapy in Germany
Autoren
M. Pape, S. Herpertz, S. Doering, H. Kessler, M. de Zwaan, A. Zeeck, A. Hartmann, T. Hofmann, M. Rose, K. Imbierowicz, F. Geiser, I. Croy, K. Weidner, J. Rademacher, S. Michalek, E. Morawa, Y. Erim, E. Skoda, M. Teufel, S. Heinzmann, C. Lahmann, E. Peters, J. Kruse, D. von Boetticher, C. Herrmann-Lingen, M. Nöhre, U. Dinger, H. Friederich, A. Niecke, C. Albus, R. Zwerenz, M. Beutel, C. Roenneberg, P. Henningsen, B. Stein, C. Waller, K. Hake, C. Spitzer, A. Stengel, S. Zipfel, K. Weimer, H. Gündel, A. Kehyayan
Erscheinungsjahr
Erschienen in:
European eating disorders review: the professional journal of the Eating Disorders Association
Background: There is ample evidence on the efficacy of different therapeutic approaches in treating eating disorders. Yet, studies on the effectiveness of inpatient/day-hospital treatment of eating disorders are rare. Method: Data were retrieved from a naturalistic multi-center effectiveness study of inpatient and day-hospital treatment in departments of psychosomatic medicine and psychotherapy in Germany (MEPP). N = 151 patients with Anorexia Nervosa (AN) and atypical AN, as well as n = 120 patients with Bulimia Nervosa (BN) and atypical BN were included. Eating disorder pathology (EDE-Q) and BMI were assessed on admission, at discharge, and 1 year after discharge. Changes over time were analysed in both outcomes. Treatment success was assessed individually using reliable change (RC) indices. Regression analyses were used to identify predictors of RC. Results: EDE-Q scores decreased in both patient groups. One year after discharge, RC was estimated in 33.8% of patients with AN and 43.3% of patients with BN. 24.2% of patients with AN and 54.3% with BN showed partial remission. Discussion: Results from this multi-center effectiveness study are comparable to those of former national and European studies. Based on the results of individual treatment success, recommendations for inpatient/day-hospital treatment can be derived. Trial Registration: The study was registered at the German Clinical Trials Register (www.drks.de; ID: DRKS00016412).
A longitudinal bifactor approach to modelling somatic symptom development in psychosomatic treatment
Autoren
T. Petzke, F. Köteles, H. Kessler, S. Doering, A. Kehyayan, M. Pape, T. Hofmann, M. Rose, K. Imbierowicz, F. Geiser, I. Croy, K. Weidner, J. Rademacher, S. Michalek, E. Morawa, Y. Erim, J. Krakowczyk, M. Teufel, S. Heinzmann, C. Lahmann, E. Peters, J. Kruse, D. von Boetticher, C. Herrmann-Lingen, M. Nöhre, M. de Zwaan, U. Dinger, H. Friederich, A. Niecke, C. Albus, R. Zwerenz, M. Beutel, C. Roenneberg, H. Sattel, P. Henningsen, B. Stein, C. Waller, K. Hake, C. Spitzer, A. Stengel, S. Zipfel, K. Weimer, H. Gündel, S. Herpertz, M. Witthöft, N. Lehnen
B. Doludda, M. Franz, J. Bogado Lopes, R. Overall, A. Rünker, I. Croy, G. Kempermann
Erscheinungsjahr
Erschienen in:
Scientific reports
As complex individualized behaviors in mice arise even when genes and environment are held constant, emerging social group structures should also depend on individual behavior. Adult hippocampal neurogenesis drives individual behavior and is involved in certain social behaviors. Would thus the emergence of social structure depend on adult-born neurons? To answer this question, we co-housed cohorts of female mice with intact and genetically diminished general adult neurogenesis in a large-scale automated tracking system for three months and analyzed the development of social behaviors over time. Not only did female mice develop stable hierarchies, we also found that, despite forming a functioning mouse society, their dominance behavior increasingly diverged over time. Specifically, neurogenesis-deficient mice showcased a greater increase in hierarchical behavior throughout the experiment. Within the social behaviors, mice showed no genotype-based preference, indicating intrinsic causes for behavioral differences. In mice with intact neurogenesis, social rank was positively correlated with adult hippocampal neurogenesis. Nevertheless, neurogenesis-deficient mice occupied higher ranks in the emerging hierarchy than their wild-type cohabitants, while displaying less individualization for this trait. The observed insistence on dominance might therefore reflect inflexible social strategies. Thus, social intelligence and flexibility, enabled by adult-born neurons, promote social adaptability, egality, and flatter hierarchies.
Decoding odor responses: universal patterns and individual signatures in psychophysiology using nonlinear models
Autoren
T. Jesgarzewsky, A. Bierling, I. Croy
Erscheinungsjahr
Erschienen in:
Chemical senses : official journal of the American Association for Chemoreception Sciences (AChemS)
Olfactory perception is a complex process driven by the chemical properties of odorants and shaped by a multitude of individual factors. As a result, predicting how an individual perceives a given odor remains challenging. We aimed to address this complexity by integrating individual response patterns, odorant properties, and psychophysiological responses into a unified model. Therefore, we tested perceptual dimensions (valence, temperature, and intensity) of 6 perceptually diverse monomolecular odorants with continuous time-series data from psychophysiological measures (respiration, heart rate, electromyography [EMG] corrugator, and EMG zygomaticus) in a sample of 41 participants. By simultaneously accounting for the odorant itself, individual rating tendencies, and both group-level and individual-specific physiological effect patterns in the nonlinear modeling process, we found that while the specific odorant and individual rating tendencies were the primary drivers of perception, the relative contributions varied significantly across perceptual dimensions. The inclusion of physiological signals significantly improved the predictive models, revealing that both generalizable (group-level) and highly individualized psychophysiological response patterns contributed to how an odor was perceived. Examination of the specific effect patterns revealed respiration and EMG corrugator as key group-level predictors for valence and intensity, while significant individual-specific effect patterns varied considerably across the perceptual dimensions. Our findings demonstrate that a comprehensive understanding of olfactory perception requires the consideration of the interplay between stimulus characteristics, idiosyncratic biases, and distinct universal versus person-specific physiological signatures, offering a more nuanced understanding of this sensory experience.
Bridging Lab and Life: A Dual-Person Paradigm for Social Interaction Research
Autoren
V. Nöring, L. Krismann, M. Franz, F. Rottstädt, I. Croy
Erscheinungsjahr
Erschienen in:
Psychophysiology : journal of the Society for Psychophysiological Research
Interpersonal synchrony, the spontaneous coordination of actions, emotions, and physiological processes, plays a crucial role in social bonding. While existing research has significantly advanced our understanding of interpersonal synchrony, many studies rely on either artificial paradigms that may limit ecological validity or naturalistic approaches that can pose challenges for achieving sufficient statistical power. To address this, we developed and validated a semi-naturalistic verbal social interaction paradigm, in which two individuals talk about a variety of standardized neutral and autobiographical emotional topics. Sixty-nine dyads (N = 138) participated and reported valence, arousal, connectedness, and dominance after each trial. Results confirmed the paradigm's reliability and validity by showing that emotional conversations, especially when sharing one's own autobiographical event, elicited higher arousal, more valence, and increased heart rate than neutral ones, with relatively stable affective responses across trials. Participants also felt more connected during emotional conversations, particularly with closer friends. In conclusion, we are optimistic that our social interaction paradigm is a useful tool for studies of dual person neuroscience by balancing experimental control and ecological validity. Its flexible design allows for adaptation across research contexts and supports broad application. This validation establishes the paradigm's reliability, enabling future hypothesis testing regarding interpersonal synchrony.
Multidomain correlates of burnout: A population-based study using supervised machine learning
Autoren
A. Monstadt, Y. Friedrich, F. Rottstädt, M. Weiss, T. Behrens, S. Casjens, J. Frost, J. Massag, I. Moor, N. Opel, L. Pfrommer, B. Schüz, A. Scherag, M. Walter, R. Mikolajczyk, I. Croy
Erscheinungsjahr
Erschienen in:
Social Psychiatry and Psychiatric Epidemiology: The International Journal for Research in Social and Genetic Epidemiology and Mental Health Services
Purpose: Burnout is a growing challenge for individuals and society and understanding risk factors is crucial to develop targeted prevention strategies. Thus, we aimed to determine whether and how burnout relates to different organisational factors, psychosocial employment conditions, sociodemographic variables and mental health. Methods: We analysed cross-sectional survey data collected in the 2023 wave with focus on occupational health within the German population-based DigiHero cohort. Using linear associations and xg-boost machine learning, we explored the relations of multidomain variables with burnout severity, which was measured with the Maslach Burnout Inventory. Machine learning results were interpreted through SHAP values. Results: We included 27,020 participants, aged 18–67 years (median 49), 65.2% female, in the analysis. The strongest predictors of burnout were effort-reward-imbalance, work-life-interference, overcommitment and poor general mental health, particularly symptoms of depression and anxiety. Compared to psychosocial employment conditions and individual mental health, organisational and sociodemographic factors were less important. However, occupation mattered and other aspects, such as extended remote work, had small, but noticeable effects. Age and income were the only sociodemographic factors that contributed. Results from xg-boost were compared to results from univariate statistics and remained robust when adjusting for sample bias through case weights. Conclusion: The study emphasises the importance of psychosocial employment conditions and individual mental health in the context of burnout, which outweigh the effects of organisational and sociodemographic factors. For practice this suggests that positive social work environments may prevent burnout while mental health problems increase vulnerability. For causal insights, prospective longitudinal studies are required.
Links between personality functioning and post-traumatic stress disorder symptoms: a network analysis
Autoren
J. Fuchshuber, H. Kessler, A. Kehyayan, M. Pape, T. Hofmann, M. Rose, K. Imbierowicz, F. Geiser, A. Bierling, K. Weidner, J. Rademacher, S. Michalek, E. Morawa, Y. Erim, M. Teufel, A. Bäuerle, S. Heinzmann, C. Lahmann, E. Peters, J. Kruse, D. von Boetticher, C. Herrmann-Lingen, M. Nöhre, M. de Zwaan, U. Dinger, H. Friederich, A. Niecke, C. Albus, R. Zwerenz, M. Beutel, C. Roenneberg, P. Henningsen, B. Stein, C. Waller, P. Wülfing, C. Spitzer, A. Stengel, S. Zipfel, K. Weimer, H. Gündel, S. Herpertz, S. Doering
Erscheinungsjahr
Erschienen in:
European Journal of Psychotraumatology: official organ of the European Society of Traumatic Stress Studies (ESTSS)
Interdisciplinary multimodal pain therapy: does the dose make a difference? ; A comparison from routine clinical care
Autoren
P. Baumbach, P. Storch, T. Weiss, W. Meissner, F. Rottstädt
Erscheinungsjahr
Erschienen in:
Der Schmerz
Background: Interdisciplinary multimodal pain therapy (IMPT) is an established treatment for patients with severe chronic pain. Little evidence is available on the role of treatment dosage and, in particular, on the association between the duration of IMPT and treatment outcome. Aim: The aim of this retrospective study was to compare the medium-term treatment success of a short inpatient (SIT, 1 week) and a long outpatient (LOT, 4 weeks) IMPT with a comparable treatment concept and comparable therapy intensity (20 h/week) in patients with severe chronic pain. Methods: Patients in both groups completed the German Pain Questionnaire at the beginning and end of IMPT as well as after 3 months. Primary outcome measures included pain-related impairment and average pain intensity at follow-up in patients of comparable sex, age as well as pain intensity and impairment at the beginning of the therapy. Results: While both groups initially showed significant treatment effects in pain-related impairment and average pain intensity, LOT patients (n = 32) reported significantly better values in both variables at 3‑month follow-up compared with SIT patients (n = 32). This was due to sustained positive effects in LOT patients and worsening in the SIT group. Conclusion: The results indicate that initial treatment effects can be observed in both treatment settings, but a longer duration of therapy seems to favour the long-term stability of treatment effects.
